High-Yield™ Pharmacology 3rd Edition by Weiss, Stephanie T. [Paperback]
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HighYield™ Pharmacology Weiss, Stephanie T.
(Sinequan) Amitriptyline (Elavil) Clomipramine (Anafranil) Imipramine (Tofranil) Desipramine (Norpramin) Nortriptyline (Aventyl, Pamelor) High High High Moderate Low Low 3. Overdoses from tricyclics are common because depressed patients may ingest large amounts of the drug in an attempt to commit suicide, and these drugs have a narrow therapeutic index. Treatment of an overdose involves a. Supportive management b. Lidocaine to reduce arrhythmias c. Physostigmine to reverse anticholinergic
(O2) are required. b. Many reactions can be produced, including: i. Hydroxylation ii. Dealkylation iii. Deamination iv. Sulfoxidation v. Oxidation c. Highly lipid soluble drugs are more readily metabolized by CYPs. 2. Reductive reactions can occur in the ER or the cytosol. 3. Hydrolytic reactions do not occur in the ER. Weiss_Ch01_001-013.qxd 6 8/27/08 10:10 AM Page 6 CHAPTER 1 D. PHASE 2 metabolic reactions are conjugative, adding highly polar groups to the drug to increase renal
Quinidine is the stereoisomer of quinine. Although quinidine can be used to treat malaria, it is more commonly used to treat arrhythmias. Both drugs prevent the parasite from polymerizing heme. ii. Side effects include cinchonism (nausea, vomiting, tinnitus, vertigo) and arrhythmias. d. Mefloquine (Lariam) is a quinine derivative that has a long half-life and can be administered orally. It is thought to work by damaging the parasite’s cell membrane. e. Tetracyclines also have antimalarial
of nucleotides into nucleic acids. Weiss_Ch11_142-151.qxd 146 9/1/08 9:16 AM Page 146 CHAPTER 11 1. Methotrexate (Trexall, Rheumatrex) is an analog of folic acid which competitively inhibits the enzyme, dihydrofolate reductase. a. Tetrahydrofolate levels are decreased. i. Decreased DNA, RNA, and protein synthesis occurs. ii. The primary effect is a decrease of thymidylate synthesis. iii. The highest activity occurs in cells with low thymidine derivatives and normal RNA and normal
Lorazepam (Ativan) antiemetic, 11 I Losartan (Cozaar) antihypertensive, 5 III Lovastatin (Mevacor) antihyperlipidemic, 6 VI Luminal amebicide antiprotozoal, 10 II Lypressin (Diapid) ADH agonist, 8 I Lysergic acid diethylamide (LSD) hallucinogen, 4 VI M Macrolide antituberculous, 9 XIII protein synthesis (50S Ribosome) inhibitor, 9 VIII Magnesium antiarrhythmic, 5 VI Magnesium hydroxide antacid, 7 X Magnesium sulfate laxative, 7 X Malaoxon cholinesterase inhibitor, 2 III Marijuana abused