Infectious Diseases: A Clinical Short Course
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LEARN THE PRINCIPLES OF CLINICAL INFECTIOUS DISEASESIN JUST THIRTY DAYS
A Doody's Core Title for 2015!
Infectious Diseases: A Clinical Short COURSE is a concise overview of this important field designed to help the busy physician, medical student, nurse practitioner, and physician assistant to understand, diagnose, and treat common infectious diseases. This unique self-instruction book is organized by system/region as opposed to pathogens?simulating how common pathogens anddisorders would be encountered in rounds or in practice.
By indicating the number of days that should be allotted to the study of each chapter, the author has created a schedule for completion of each lesson. A wide array of tables that summarize the methods of clinical assessment, anti-infective agent doses, and drug toxicities--facts that do not require memorization, but do need to be referred to when caring for patients--facilitate this condensed learning schedule. There is no better resource for learning to associate pathogens with the corresponding impact on patients than Infectious Diseases.
- Key Points summarize the most important facts when managing each infection and facilitate board review
- Guiding Questions begin each chapter
- An estimate of the potential severity of each disease gives you a sense of how quickly you should initiate treatment
- Numerous case examples highlight real-world clinical application of the content
- Dozens of color plates depict major pathogens
- All chapters have been updated to reflect the most current treatment and diagnostic guidelines from the Infectious Diseases Society of America
- NEW! Antibiograms for each major antibiotic class provide a visual depiction of the spectrum of each individual antibiotic; a table listing the most commonly used outpatient antibiotics and their dosing; and much more
High levels of direct or conjugated bilirubin suggest cholestasis, and high levels of indirect or unconjugated bilirubin usually indicate red blood cell hemolysis that can develop in patients with viral hepatitis who also have glucose-6-dehydrogenase deficiency or sickle cell anemia. Significant elevation of the prothrombin time is a bad prognostic sign. A prothrombin time above 100 indicates irreversible hepatic damage, and these patients should be promptly considered for liver transplant. In
CLINICAL COURSE AND DIAGNOSIS After a 4-week incubation period, patients infected with hepatitis A usually experience the acute onset of a flu-like illness. The disease is usually self-limiting, resolving within 2-3 months (Figure 8.3). However, 10% of hospitalized patients follow a relapsing course characterized by improvement followed by a second episode of jaundice that usually develops 6-12 weeks later, but that can occur up to 6 months after the first symptomatic attack. Prolonged, but
Streptococcus pneumoniae, is 10-100 times more frequent in HIV-positive than in HIV-negative patients. TB can occur at any degree of immune deficiency, but it is particularly frequent in patients who grew up in developing countries. With a lobar infiltrate in a patient with a CD4 count above 200/μm3, the presumptive diagnosis is bacterial pneumonia. Empiric treatment should start with amoxicillin–clavulanate, a cephalosporin, or one of the quinolones with activity against gram-positive bacteria.
or less. In nature, intrinsic resistance is found in 1 out of every 106 organisms; therefore, the likelihood of selecting for a resistant pathogen also depends on the concentration of bacteria in the infected organ. In pneumonia and intra-abdominal infections, bacterial counts are often $109; therefore, achieving a high AUC/MIC is most important for these infections. In patients with sepsis as well as for infections caused by Pseudomonas, many experts recommend utilizing two antibiotics (double
occurs among the clinical manifestations of the pathogens associated with acute CAP. However, constellations of symptoms, signs, and laboratory findings serve to narrow the possibilities. By developing an ability to focus on a few pathogens or to identify a specific pathogen, clinicians can better predict the clinical course of pneumonia and can narrow antibiotic coverage. Streptococcus Pneumoniae PATHOGENESIS Pathogenic strains of S. pneumoniae have a thick capsule that prevents PMN binding