Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause
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Presenting the most current and relevant information on the diagnosis and management of primary ovarian insufficiency, also known as premature ovarian failure (POI/POF), this book presents two equally important voices. The first is the scientific, evidence-based voice discussing the latest information on POI/POF in a concise and logical fashion: etiologies, symptoms, genetics, mechanisms, associated conditions, as well as psychological and lifestyle considerations. The second voice presents the first-person stories of affected women, who are often faced with a diagnosis of irreversible infertility at a very young age and who somehow learn to live with great uncertainty about their ability to create a family – a core identity issue for many women. It is thus not simply a clinical, case-based presentation, but a more collaborative effort between clinicians who are well-versed in the field and women who have POI/POF. Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause will therefore be an excellent practical yet personal reference for OB/GYNs, reproductive medicine specialists, and any clinician, nurse or health care worker treating women living with POI/POF.
fertilizable oocytes. Until that day, much work remains to better understand all the quality controls that nature has instituted to produce quality eggs ready for fertilization and new generations. References 1. Ramalho-Santos M, Willenbring H. On the origin of the term “stem cell”. Cell Stem Cell. 2007;1:35–8. 2. Richards RJ. The tragic sense of life: Ernst Haeckel and the struggle over evolutionary thought. Chicago: University of Chicago Press; 2008. 3. Haeckel E. Natürliche
of ovarian reserve occurring at menopause Ovarian Reserve Menopause 1 Defining Menopause: What Is Early, What Is Late? 3 ovarian reserve, symptoms are not always as severe as regular menopause . In one study which collected internet surveys from 160 women with POI on POIspecific symptoms, commonly reported symptoms included mood swings and mental fog (75 %); hair loss, dry eyes, cold intolerance, and joint clicking (50 %); tingling in limbs and low blood pressure (33 %); hypothyroidism
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet. 2001;27(2):159–66. 32. Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004;131(4):933–42. 33. Pal T, Keefe D, Sun P, Narod SA. Fertility in women with BRCA mutations: a case–control study. Fertil Steril.
first being when he was in med school years and years ago. I researched POF and discovered that the NIH was doing clinical trials. At the NIH, the doctors discovered that my thyroid hormone was very abnormal. I have Hashimoto’s Thyroiditis, and that needed to be addressed when I got back home. I had an MRI and they discovered a microadenoma (small tumor) on my pituitary gland. I had a bone density scan and yes, in fact, I did have osteopenia in my bones as a result of lack of estrogen for most of
offered donor egg cycles. They chose a fresh donor cycle that produced enough good quality embryos for several pregnancies. They conceived with a single embryo transfer and are now deciding how long to wait between children. Postpartum, Maureen immediately returned to her oral contraceptives. She was concerned that without her hormonal support she might experience significant postpartum depression. Turner Syndrome Women with TS often know about their reproductive challenges from the time they